Extreme overdosage may lead to coma, areflexia, cardiorespiratory despair and apnea. The results of overdosage might be controlled with benzodiazepine antagonist flumazenil.
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The state of Ohio used midazolam during the execution of Dennis McGuire in January 2014; it took McGuire 24 minutes to die following the treatment started off, and he gasped and seemed to be choking throughout that time, leading to questions on the dosing and timing on the drug administration, in addition to the option of medicine.[85]
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This medication is utilized by kids right before a procedure or anesthesia to result in drowsiness, lessen anxiousness, and lead to forgetfulness more info of the surgical procedure or technique. It should be applied whilst the kid is under the care of a well being Qualified.
You could experience drowsy for 24 to forty eight hrs once the injection. Avoid driving or hazardous action till the consequences of midazolam have worn off totally. Dizziness or drowsiness may cause falls, incidents, or extreme injuries.
For the initial dose, use 1 five mg spray in one nostril. If your seizure cluster proceeds for a minimum of 10 minutes just after the initial dose, a next five mg dose can be given Should your Health care service provider has instructed you to provide a next dose.
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[eighty two] Midazolam functions to be a sedative but will are unsuccessful to render the condemned prisoner unconscious, at which era vecuronium bromide and potassium chloride are administered, halting the prisoner's respiratory and coronary heart, respectively. Since the condemned prisoner is just not rendered unconscious but is just sedated, the administration of vecuronium bromide and potassium chloride could potentially cause Intense ache and stress in the person getting executed.[83]
Grapefruit may possibly interact with midazolam and induce Negative effects. Avoid consuming grapefruit merchandise for a brief time immediately after having midazolam.
Midazolam can slow or cease your respiration, especially if you've got just lately made use of an opioid medication or Alcoholic beverages. Midazolam needs to be made use of only in a healthcare facility, dentist Business, or other clinic placing the place any significant Uncomfortable side effects might be rapidly treated.